The UNLOCK validation study Primary Care COPD Patients Compared with Large Pharmaceutically-Sponsored COPD Studies has been published in PLOS ONE. The studyevaluated the external validity of six LPCS (ISOLDE, TRISTAN, TORCH, UPLIFT, ECLIPSE, POET-COPD) on which current guidelines are based. It found that primary care COPD patients stand out from patients enrolled in LPCS in terms of gender, lung function, quality of life and exacerbations. It concluded more research is needed to determine the effect of pharmacological treatment in mild to moderate patients and encourages future guideline makers to involve primary care populations in their recommendations.
The study authors are Annemarije L. Kruis, Björn Ställberg, Rupert C. M. Jones, Ioanna G. Tsiligianni, Karin Lisspers, Thys van der Molen, Janwillem H. Kocks, Niels H. Chavannes. View the study at http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090145